Effect of Metformin on Weight and Biochemical Indices in over Weight and Obese Diabetics

Abstract

An effect of metformin on weight and biochemical parameter for 6 month or longer is extensively studied while the effect of only 3 months is not fully elaborated. In our retrospective study we collect and analyze data for the effect of metformin (3 months) on obese newly diagnosed diabetic on diet control (Mediterranean diet with reduce total calories intake) following a registered Nutritionist at Elkodes clinic. We include data of all overweight and obese newly diagnosed diabetics before and after 3 months period of starting metformin in addition to diet control. Patients on anti-lipid or weight reduction therapy and patient with known liver or renal disease were excluded. Paired T test was used. The mean weight, T cholesterol, Triglyceride, LDL-C and as expected HbA1c (72.04 Kg, 182.4 mg/dl, 135 mg/dl, 85.6 mg/dl, 6.1) was significantly lower after metformin compared to before therapy (83.6 Kg, 208.5 mg/dl, 169mg /dl, 113mg/dl, 7.9) respectively. Renal and liver functions were not statistically different. Our study shows that metformin can have significant favorable effect on weight and lipid profile even for (3 months) use without effect on liver function. Most previous evidence demonstrates the effect of metformin after 6 months or longer.