Extracorporeal Cardiopulmonary Resuscitation for Refractory Cardiac Arrest: Patient Selection Under Extreme Time Pressure

Authors

  • Vincenzo Altomare Department of Cardiac Intensive Care, Latium Institute of Cardiovascular Science, Rome, Italy Author
  • Ida Brännström-Vik Department of Emergency Medicine, Bothnia Bay Institute of Cardiology, Luleå, Sweden Author
  • Krystian Lasota Department of Clinical Perfusion, Mazurian Institute of Cardiology, Olsztyn, Poland Author

DOI:

https://doi.org/10.5281/zenodo.22365792

Abstract

Extracorporeal cardiopulmonary resuscitation (ECPR) substitutes a mechanical circuit for the heart and lungs when
conventional resuscitation has failed, buying time for a reversible cause of arrest to be identified and treated. The
concept is mechanically straightforward; the clinical question is whether it can be deployed fast enough, and in the right
patients, to translate that physiological rescue into a meaningful chance of neurologically intact survival. Three
randomized trials published within three years of each other have now tested this question directly, with results that diverge
more than the shared underlying technology might suggest.

References

Yannopoulos D, Bartos JA, Raveendran G, et al. "Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation" (ARREST). Lancet 396(2020):1807-1816.

Belohlavek J, Smalcova J, Rob D, et al. "Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest" (Prague OHCA). JAMA 327(2022):737-747.

Suverein MM, Delnoij TSR, Lorusso R, et al. "Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest" (INCEPTION). N Engl J Med 388(2023):299-309.

Gomes DA, Presume J, Ferreira J, et al. "Extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized clinical trials". Intern Emerg Med 18(2023):2113-2120.

[Authors not independently confirmed beyond the indexed abstract]. "The impact of selection criteria and study design on reported survival outcomes in extracorporeal cardiopulmonary resuscitation (ECPR): a systematic review and meta-analysis". Scand J Trauma Resusc Emerg Med 29(2021):142.

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Published

2024-08-27

How to Cite

Extracorporeal Cardiopulmonary Resuscitation for Refractory Cardiac Arrest: Patient Selection Under Extreme Time Pressure. (2024). Journal of Heart and Cardiovascular Science, 5(1), 20-23. https://doi.org/10.5281/zenodo.22365792