Vitamin D Supplementation in Northern European Winters: Evidence, Dose and the Gap Between Guidance and Practice
DOI:
https://doi.org/10.5281/zenodo.22275642Keywords:
Vitamin D, 25-hydroxyvitamin D, Supplementation, Northern Europe, FortificationAbstract
Two authoritative reviews of vitamin D status in Northern Europe disagree by a wide margin. One reports that 43 to 92 per cent of
adults and 89 to 97 per cent of teenage girls have serum 25-hydroxyvitamin D below 50 nmol/L; another reports that deficiency at
the same threshold occurs in under 20 per cent of the population in Northern Europe, against 30 to 60 per cent in Western,
Southern and Eastern Europe. The discrepancy is not a simple error. Where fortification policy and a supplementation tradition
exist, latitude runs inversely to serum concentration, so the countries with least winter sunlight are not reliably the worst affected.
Dose guidance is similarly unsettled, ranging from a reference intake of 400 to 800 international units daily to expert consensus of
800 to 2,000, and up to 4,000 for defined groups. Across the European general population 13.0 per cent fall below 30 nmol/L and
40.4 per cent below 50.
References
Lips P, Cashman KD, Lamberg-Allardt C, Bischoff-Ferrari HA, Obermayer-Pietsch B, Bianchi ML, et al. "Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society". Eur J Endocrinol 180(2019):P23-P54.
Holick MF. "Vitamin D deficiency". N Engl J Med 357(2007):266-281.
Northern Europe review authors. "Vitamin D deficiency and its health consequences in Northern Europe". In: Vitamin D: Physiology, Molecular Biology and Clinical Applications. Humana Press, New York (2010):413-430.
Webb AR, Kline L, Holick MF. "Influence of season and latitude on the cutaneous synthesis of vitamin D3". J Clin Endocrinol Metab 67(1988):373-378.
Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Mascarenhas MR, Haq A, et al. "Vitamin D supplementation guidelines". J Steroid Biochem Mol Biol 175(2018):125-135.
Cashman KD, Hill TR, Lucey AJ, Taylor N, Seamans KM, Muldowney S, et al. "Estimation of the dietary requirement for vitamin D in healthy adults". Am J Clin Nutr 88(2008):1535-1542.
DACH recommendation investigators. "Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: a randomized trial". Nutrients 9(2017):30.
Pludowski P, Takacs I, Boyanov M, Belaya Z, Diaconu CC, Mokhort T, et al. "Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: a Central and Eastern European expert consensus statement". Nutrients 14(2022):1483.
Body mass index investigators. "The association between body mass index and vitamin D supplement use among adults in the United States". Nutrients 11(2019):2508.
Cashman KD, Dowling KG, Skrabakova Z, Gonzalez-Gross M, Valtuena J, De Henauw S, et al. "Vitamin D deficiency in Europe: pandemic?". Am J Clin Nutr 103(2016):1033-1044.
Institute of Medicine. "Dietary reference intakes for calcium and vitamin D". National Academies Press, Washington DC (2011).
Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. "The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know". J Clin Endocrinol Metab 96(2011):53-58.
Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. "Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline". J Clin Endocrinol Metab 96(2011):1911-1930.
Bouillon R. "Comparative analysis of nutritional guidelines for vitamin D". Nat Rev Endocrinol 13(2017):466-479.
Scientific Advisory Committee on Nutrition. "Vitamin D and health". Public Health England, London (2016).
Cashman KD. "Vitamin D deficiency: defining, prevalence, causes, and strategies of addressing". Calcif Tissue Int 106(2020):14-29.
Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, et al. "Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D". Br J Clin Pharmacol 84(2018):2194-2207.
Binkley N, Dawson-Hughes B, Durazo-Arvizu R, Thamm M, Tian L, Merkel JM, et al. "Vitamin D measurement standardization: the way out of the chaos". J Steroid Biochem Mol Biol 173(2017):117-121.
Cashman KD, Kiely M. "Tackling inadequate vitamin D intakes within the population: fortification of dairy products with vitamin D may not be enough". Endocrine 51(2016):38-46.
Kiely M, Black LJ. "Dietary strategies to maintain adequacy of circulating 25-hydroxyvitamin D concentrations". Scand J Clin Lab Invest Suppl 243(2012):14-23.
Itkonen ST, Erkkola M, Lamberg-Allardt CJE. "Vitamin D fortification of fluid milk products and their contribution to vitamin D intake and vitamin D status in observational studies: a review". Nutrients 10(2018):1054.
Jaaskelainen T, Itkonen ST, Lundqvist A, Erkkola M, Koskela T, Lakkala K, et al. "The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population". Am J Clin Nutr 105(2017):1512-1520.
Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, et al. "Prevention of nonvertebral fractures with oral vitamin D and dose dependency". Arch Intern Med 169(2009):551-561.
Bolland MJ, Grey A, Avenell A. "Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis". Lancet Diabetes Endocrinol 6(2018):847-858.
Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. "Vitamin D supplements and prevention of cancer and cardiovascular disease". N Engl J Med 380(2019):33-44.
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. "Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data". BMJ 356(2017):i6583.
Respiratory infection investigators. "Assessing the impact of vitamin D supplementation on respiratory infections in children and adolescents: a cross-sectional study". Medicina 60(2024):1794.
Paediatric dosing investigators. "Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study)". Ital J Pediatr 45(2019):18.
Pregnancy determinants investigators. "Prenatal determinants of maternal 25(OH)D levels at delivery: the role of diet and supplement use in a cross-sectional study in Greece". Nutrients 17(2025):2401.
Cashman KD, Ritz C, Kiely M. "Improved dietary guidelines for vitamin D: application of individual participant data (IPD)-level meta-regression analyses". Nutrients 9(2017):469.
Vieth R. "Vitamin D supplementation: cholecalciferol, calcifediol, and calcitriol". Eur J Clin Nutr 74(2020):1493-1497.
Heaney RP. "Guidelines for optimizing design and analysis of clinical studies of nutrient effects". Nutr Rev 72(2014):48-54.
Spiro A, Buttriss JL. "Vitamin D: an overview of vitamin D status and intake in Europe". Nutr Bull 39(2014):322-350.
Lips P, de Jongh RT, van Schoor NM. "Trends in vitamin D status around the world". JBMR Plus 5(2021):e10585.

