Digital Twins and Computational Modelling in Cardiovascular Care: Where Simulation Currently Earns Clinical Trust
DOI:
https://doi.org/10.5281/zenodo.22365953Abstract
The phrase 'digital twin' has become common shorthand for computational models built from an individual patient's own
anatomy and, increasingly, physiology, intended to simulate a procedure or predict a physiological measurement before it is
performed or measured directly. In cardiovascular care, this idea has progressed furthest not as a single unified technology
but as a set of distinct applications, each accumulating its own evidence base at its own pace.
References
Norgaard BL, Leipsic J, Gaur S, et al. "Diagnostic Performance of Noninvasive Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography in Suspected Coronary Artery Disease" (NXT trial). J Am Coll Cardiol 63(2014):1145-1155.
Douglas PS, Pontone G, Hlatky MA, et al. "Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease" (PLATFORM trial). Eur Heart J 36(2015):3359-3367.
[PREDICT-LAA randomized study of patient-specific computational simulation (FEops HEARTguide) versus standard CT-based sizing for Amplatzer Amulet left atrial appendage closure, as summarized in company/press reporting of the trial results, 2023].
